2021). For instance, RBPs such as TTP facilitate mRNA degradation, thereby limiting the production of pro-inflammatory factors (Sandler et al. 2011). It has been previously reported that TTP knockout mice display a more pronounced inflammatory response compared with their wild-type littermates (Taylor et al. 1996). Moreover, suppression the TTP expression has been associated with worsened heart failure prognosis due to elevated levels of inflammatory factors, such as TNF-α and IL-6 (Streicher et al. 2010). Here, TNF is linked to heart failure.