Immunoblot analysis revealed that the amount of the mitochondrial fission protein DRP1 was increased, whereas that of the mitochondrial fusion protein OPA1 was reduced, in LV tissue of MetS + Ala rats compared with that of CONT + Ala rats, and that these effects were attenuated in MetS + Arg rats (Figure 3h,i). Here, OPA1 is linked to metabolic syndrome.