AKT1 and AKT2 activating mutations are rare in PC (0.9%), whereas AKT1 and AKT2 upregulation is more common, especially in advanced disease (up to 4.5%, 2%, and 4.7%, respectively) which correlates with the Gleason score and invasive progression [44, 45]. The gene discussed is AKT1; the disease is pachyonychia congenita.