BSCL2 and Insulin resistance: Although Seipin−/− mice exhibit severe insulin resistance under fed or short‐term fasting conditions,22, 26 our study found no significant differences in key insulin signalling factors, such as pAKT, or in the mRNA levels of key players in the insulin signalling pathway between Seipin−/− and WT mice 12–24 h post‐PHx.