Here, we assessed the potential association between antecedent WBC MGMT methylation state in healthy people and incident colon cancer (CC), glioblastoma (GB), and diffuse large B-cell lymphoma (DLBCL), three tumor forms known to have MGMT epimutations affecting 20–40% of all tumors [17, 27–30]. This evidence concerns the gene MGMT and malignant colon neoplasm.