Moreover, in a nested case–control ancillary study in the Women’s Health Initiative (WHI), low-level mosaic BRCA1 promoter methylation in white blood cells (WBC) from healthy females was associated with a significantly elevated hazard ratio for incident triple-negative breast cancer (TNBC) as well as for incident high-grade serous ovarian cancer (HGSOC), both diagnosed many years after WBC DNA sampling [15]. This evidence concerns the gene BRCA1 and triple-negative breast carcinoma.