Transcriptional analyses and antibody-based protein detections performed on B-ALL and AML further identify the unparalleled concurrent expression of Syndecan-1/CD138, Syndecan-2/CD362, Endoglycan, Podocalyxin-like 2 and Glypican-2 (Fig. 4). The gene discussed is PODXL2; the disease is acute lymphoblastic leukemia.