For instance, both upregulation of distinct splice forms of CD44 (CD44v6 and CD44v9) in the neoplastic cells and high levels of circulating CD44 fragments typically correlate with overall survival, disease progression and recurrence in a spectrum of haematological neoplasia, including diffused large cell lymphomas (DLCL), plasma cell dyscrasias, i.e., MM, MGUS and myelodysplastic syndrome, Hodgkin’s disease and Burkitt’s lymphoma, B-CLL and childhood leukemia [34, 110–114]. This evidence concerns the gene CD44 and B-cell chronic lymphocytic leukemia.