Since it has been demonstrated that in different tissue districts (foremost cartilage) Decorin makes a significant contribution to the supramolecular assemblies and flexibility of “collagen-proteoglycan matrices”, it is conceivable that the modulatory role of Decorin in MM progression is balanced between its influences on growth factor-signalling dynamics and modifications of the architecture of the tumour microenvironmental ECM. Here, DCN is linked to neoplasm.