Aberrant translation of Fibromodulin in CLL-B cells seems to protect neoplastic lymphocytes from irradiation-induced apoptosis in a p53-dependent manner and, vice versa, RNAi-based knockdown of Fibromodulin in patient-derived CLL-B cells elicits regulated cell death [108]. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.