This finding together with the frequency of NG2/CSPG4 expression on plasmacytoid dendritic leukemia cell lines lacking MLL abnormalities and displaying the immunophenotype CD34+/CD38+/CD45+/CD123+/HLADR+ have led investigators to assume that in the absence of MLL rearrangements, expression of the proteoglycan on leukemic cells may be dictated by the context within which leukemogenesis is initiated [94]. This evidence concerns the gene CSPG4 and leukemia.