The clinical presentation was mainly characterized by fulminant hepatitis and severe coagulopathy, on day 9 alanine transaminase (ALT) decreasing to 523 U/L with no sign of normalization of coagulation despite multiple transfusion (PT ratio 4,83; aPTT 1,67, fibrinogen 90 mg/dl). The gene discussed is GPT; the disease is Fulminant hepatitis.