Astrocytes highly express several chaperones and protein homeostasis regulators, including the HSP20 gene Hspb1 and the extracellular chaperone/ lipid transport APOJ apolipoprotein gene Clu, suggesting important roles for astrocytes in mediating proteostasis, especially under stressors like sepsis-related inflammation [24]. The gene discussed is CLU; the disease is Sepsis.