In detail, m7G dysregulation of tRNAs mediated by METTL1 increases the translation of genes associated with extracellular matrix remodelling, an important factor contributing to chemoresistance in cancers, including LOXL2, which facilitates osteosarcoma progression and chemoresistance to doxorubicin.42 This evidence concerns the gene METTL1 and osteosarcoma.