In recurrent HCC after radiofrequency ablation (RFA), elevated METTL1 expression facilitates the translation of transforming growth factor beta receptor‐2 (TGF‐β2), inducing polymorphonuclear MDSC (PMN‐MDSC) accumulation and decreasing CD8+ T‐cell infiltration, resulting in an immunosuppressive tumour microenvironment.60 This evidence concerns the gene METTL1 and hepatocellular carcinoma.