METTL1 up‐regulates the expression of the chemokines C‐X‐C motif chemokine ligand 5 (CXCL5) and CXCL8 in a m7G‐dependent manner, leading to myeloid‐derived suppressor cell (MDSC) accumulation and immunosuppression in HCC and intrahepatic cholangiocarcinoma (ICC).59, 60. This evidence concerns the gene METTL1 and intrahepatic cholangiocarcinoma.