CDK4 and neoplasm: Furthermore, our data indicated that overexpression of METTL1 enhances abemaciclib, a CDK4/6 inhibitor, which targets the RB1 tumour suppressor protein and causes G1/S phase cell cycle arrest in tumour cells, and the combined treatment of abemaciclib with METTL1 lentivirus (LV‐METTL1) is more effective at inhibiting tumour growth than either treatment alone.38