This study further revealed the critical role of METTL1‐mediated m7G tRNA modification in accelerating ICC cell survival and progression by selectively regulating the translation of oncogenic transcripts, including the cell‐cycle‐related mRNAs cyclin A2 (CCNA2), cyclin D2 (CCND2), CDK6 and CDK8, as well as EGFR pathway genes.63 This evidence concerns the gene CCNA2 and intrahepatic cholangiocarcinoma.