METTL1‐mediated m7G tRNA modification selectively regulates the translation of DNA‐dependent protein kinase catalytic subunit (DNA‐PKcs) or DNA ligase IV with increased frequencies of m7G ‐related codons after IR treatment, thereby resulting in increased nonhomologous end‐joining (NHEJ)‐mediated DNA DSB repair efficiency and rendering HCC cells resistant to IR.70 The gene discussed is METTL1; the disease is hepatocellular carcinoma.