Tag‐single nucleotide polymorphism analysis in MS patients revealed that a functional variant (rs10877013) strongly affects the activity of one enhancer in the 12q13.3–12q14.1 region in an allele‐dependent and orientation‐dependent manner, which could be the cause of the alteration in KIF5A–CYP27B1–METTL1–FAM119B locus gene expression due to the promoter multigene interactions observed in the region.117. Here, CYP27B1 is linked to myeloid sarcoma.