ATM and Ataxia-telangiectasia: Mutations in ATM (ataxia telangiectasia), TP53 (Li Fraumeni’s syndrome) or ERCC6/8 (Cockayne’s syndrome) come with a different profile of heightened radiosensitivity and/or radiosuspectibility (El-Nachef et al. 2021; Foray et al. 2016; Deschavanne and Fertil 1996).1* However, direct cellular actors impaired apart from DNA remain poorly illuminated.