A cascade of pro-tumorigenic factors, including IL6, VEGFA, IL11, PDGFA, and CXCL12, further amplify the formation of complex microenvironments that support tumor cell colonization and proliferation, exacerbating the progression of CRLM (Dou et al. 2018; Coulouarn 2015). This evidence concerns the gene PDGFA and neoplasm.