Similarly, in patients with SSc-ILD+, MMP-3, MMP-7, MMP-9, MMP-10, and TIMP-1 levels were not associated with antibody positivity status (anti-nuclear antibodies, anti-centromere antibodies and anti-topoisomerase I antibodies), ILD and CTD duration, received treatments (csDMARDs, bDMARDs, and vasodilators), or the presence of other SSc clinical characteristic (renal impairment, cardiac involvement, Raynaud’s phenomenon, esophageal dysfunction, calcinosis, and synovitis) (data not shown). The gene discussed is TIMP1; the disease is synovitis.