A heterozygous missense gPV in HOXB13 (NM_006361.6; c.251 G > A; p.(Gly84Glu)) was identified in a male (UPN090) with a melanoma at the age of 63 years, a prostate cancer at the age of 64 years and a lung cancer at the age of 70 years (Table 1). Here, HOXB13 is linked to prostate cancer.