MAX and pheochromocytoma: A missense variant in MAX (NM_002382.5; c.220 A > G; p.(Met74Val)), reported as a VUS in ClinVar, was identified in a male (UPN078) who presented with a pituitary gland cancer at the age of 31 years, a pheochromocytoma at the age of 56 years and he also had acromegaly (Table 1).