Patients with biallelic gPVs in RECQL4 have been found to develop cancer [22] and other genes that are a part of the RECQL gene family, including RECQL2 (OMIM: 604611) and RECQL3 (OMIM: 604610) have been associated with syndromes predisposing to both malignant and benign neoplasms [23, 24]. Here, RECQL4 is linked to cancer.