A predicted splice donor site loss variant was identified in POT1 (NM_015450.3; c.255+1 G > T) in a female (UPN232; Table 1) who presented with an ovarian cancer at the age of 43 years, multiple melanomas (ages 55, 72 and 74 years), a thyroid cancer, a lymphoma and a basal cell carcinoma (all at the age of 60 years), a lung cancer at the age of 62 years and a soft tissue sarcoma at the age of 79 years (Table 1). This evidence concerns the gene POT1 and thyroid gland carcinoma.