A gPV in PTEN (NM_000314.8; c.253+5 G > C) with a predicted splice donor site loss was identified in a female (UPN133) who developed an atypical breast fibroadenoma at the age of 33 years, a breast cancer at the age of 45 years, and an endometrial cancer and a benign pancreatic tumor and a meningioma at the age of 46 years (Table 1). Here, PTEN is linked to benign neoplasm of pancreas.