Furthermore, it has shown that 2,3,5,4’-tetrahydroxy-stilbene-2-O-β-d-glucoside (TSG) inhibits the progression of nonalcoholic fatty liver disease (NAFLD) by increasing the expression of SIRT5, thereby preventing oxidative injury and ameliorating mitochondrial dysfunction, attenuating hepatic steatosis [115]. Here, SIRT5 is linked to metabolic dysfunction-associated steatotic liver disease.