In contrast, while Lac or PD-1 antibody treatment did not significantly alter infiltration of CD4+ and CD8+ T cells into tumors (Fig. EV5D,E), these treatments activated tumor-infiltrating T cells as revealed by enhanced expression of IFNγ and perforin (Figs. 7I,J and EV5F,G). This evidence concerns the gene LCT and neoplasm.