Mechanistically, ischemic hearts lacking MIAT in CMs exhibit significantly reduced expression of HF-associated genes (Nppa, Nppb, and Myh7), proapoptotic genes (p53 and Bak1), and profibrotic genes (Col3a1, Col6a1, Postn, and Snail1). The gene discussed is NPPA; the disease is hydrops fetalis.