STAT3 and colorectal carcinoma: We particularly observed a decrease in IL17-producing T cells (CD4+ IL17+) (Supplementary Fig. 2f), a pathogenic subpopulation of CD4+ T cells known to play a critical role in CRC development as evidenced by reduced expression of IL-6, STAT3, IFNγ, and TNFα, leading to fewer and smaller tumors in IL-17A-deficient mice12.