To test whether ERK inhibition kills CRC by necroptosis we examined whether death of oncogenic RAS-expressing CRC cells HCT116 [26] caused by the ERK inhibitor SCH 772984 [27] is blocked by necrosulfonamide (NSA), a widely used small molecule MLKL inhibitor that binds MLKL at Cys86 [3] and suppresses necroptosis by preventing MLKL incorporation in the plasma membrane [3]. The gene discussed is MLKL; the disease is colorectal carcinoma.