VEGFA and breast cancer: In a polyomavirus middle T antigen-overexpressing BC model, TAMs promoted cancer cell intravasation by partly inducing angiogenesis via VEGFA secretion, thereby increasing blood vessel density.128 In addition, a subset of Tie2+ TAMs transdifferentiate into perivascular macrophages that promote vascular leakage and directly facilitate the intravasation of tumor cells.129–131 TANs also promote tumor cell intravasation but through different processes.