RCC1 and neoplasm: They participate in formating an inflammatory and fibrotic microenvironment that favors the growth and dissemination of metastatic tumor cells in the liver.234 In addition, exosomes can carry CD39 and CD73, which inhibit T-cell function and aid tumor escape from immune surveillance.241 Neutrophils can release NETs, which contain DNA components that promote the proliferation and migration of tumor cells by activating CCDC25 (a cell cycle regulatory protein), thus facilitating liver metastasis.242