EGFR and neoplasm: This confers the ability to metabolize fructose and enhances the proliferative potential of tumor cells following metastasis.244 In the context of liver metastasis, elevated SERPINE2 expression has been observed to enhance epidermal growth factor receptor (EGFR) signaling, which is conducive to the proliferation of tumor cells.245 The expression of SERPINE2 is influenced by the status of DNA methylation, thereby indicating that epigenetic alterations may also affect the process of liver metastasis.246