These findings further validated that DHCR7 is a novel potential therapeutic target.464 Sterol O-acyltransferase 1 (SOAT1), which is overexpressed in gastric cancer, promotes lipid synthesis, induces lymphangiogenesis, and promotes gastric cancer LNM by upregulating VEGF-C expression. The gene discussed is DHCR7; the disease is gastric cancer.