DAMTS10, NELL1, and RXFP3 are regarded as liver metastasis-specific genes, exhibiting mutations that are exclusive to liver metastatic regions but are absent in CRC lacking liver metastasis.243 Liver metastatic CRC cells upregulate the GATA6 transcription factor, increaseing the expression of aldolase B (ALDOB). The gene discussed is RXFP3; the disease is colorectal carcinoma.