ITGAM and breast neoplasm: Myeloid cells and their progenitors within PMN help establish chronic inflammation in secondary organs, which may be an immune response to infection.91 This inflammation, in turn, compromises the immune system’s ability to initiate an effective response, thereby facilitating the successful establishment of metastatic lesions.92 Primary breast tumors can induce the mobilization of CD11b+ myeloid cells to the lungs, creating an immunosuppressive microenvironment that dampens the cytotoxic activities of NK93 and T cells,94 thus promoting metastatic colonization in the lung.