In a polyomavirus middle T antigen-overexpressing BC model, TAMs promoted cancer cell intravasation by partly inducing angiogenesis via VEGFA secretion, thereby increasing blood vessel density.128 In addition, a subset of Tie2+ TAMs transdifferentiate into perivascular macrophages that promote vascular leakage and directly facilitate the intravasation of tumor cells.129–131 TANs also promote tumor cell intravasation but through different processes. This evidence concerns the gene VEGFA and cancer.