Moreover, interaction between SOX2 and YAP/TAZ was evident in the nucleus of breast tissues, with significant increase in the interaction between YAP/SOX2 (p < 0.001) and TAZ/SOX2 (p < 0.001) in the breast tumors in comparison to their respective adjacent normal tissues (Fig. 1c; supplementary Fig. S8a, b). Here, SOX2 is linked to breast neoplasm.