Moreover, ALDH+ cells isolated from patient breast tumors exhibited elevated expression of YAP, TAZ, and SOX2 (Fig. 1g; Supplementary Fig. S9a), concomitant with enhanced interaction between YAP/TAZ, YAP/SOX2 and TAZ/SOX2 in the nucleus (Fig. 1h; Supplementary Fig. S9b). This evidence concerns the gene SOX2 and breast neoplasm.