SPG7 and Spastic paraparesis: Corticospinal tract impairment, leading to spastic paraparesis, is a common consequence of SPG7 RDVs and the hallmark symptom of hereditary spastic paraplegia type 7 (HSP7) [24] While patient phenotypes can evolve over time, spasticity was absent in 8% of individuals with biallelic RDVs and 40% with monoallelic RDVs during follow‐up.