MYO5B and microvillus inclusion disease: In MVID, MYO5B dysfunction leads to the mislocalization of numerous apical components, including sodium-glucose cotransporter 1, aquaporin7, CDC42, sucrase-isomaltase, alkaline phosphatase, sodium-hydrogen exchanger 3, phosphoinositide-dependent protein kinase 1, and cyclic guanosine monophosphate–dependent protein kinase, but cystic fibrosis transmembrane regulator protein is retained at the apical surface (47, 48, 49).