Upon the tumor-killing photothermal effect generated byTBTP-Bz under 808 nm laser irradiation, the temperature elevationfacilitates the deformation of the AMFL and in situ drug release,substantially improving favorable delivery efficiencies of MSA-2 andits STING-stimulating activity on both cancer cell and DCs, thus triggeringimmune responses to switch the immunologically “cold”tumor to a more sensitive “hot” one. Here, STING1 is linked to neoplasm.