Its photothermal stimulation induces immunogenic cancercell death and promotes the precise release of MSA-2, thus boostingSTING activation and STING-mediated type I interferon production.Significantly, single-dose photoimmunotherapy effectively suppressesabscopal tumor growth and provokes an immune memory effect to inhibitpostsurgical recurrent and rechallenged tumors. The gene discussed is STING1; the disease is neoplasm.