PRNP and variant Creutzfeldt-Jakob disease: All infected mice showed the same characteristic neuropathology and diglycosylated PrP dominant PrPSc type (Fig 7B) as seen in previous transmissions of type 5 PrPSc to FVB/N mice [8] and congruent with transmissions of 129MM or 129MV vCJD patient brain samples to these mice.