PRNP and variant Creutzfeldt-Jakob disease: The morphologies and distribution of the florid PrP plaques in the cortex and midbrain were consistent with the early stages of prion infection seen in 129MM Tg35c mice following challenge with prions from 129MM vCJD patient brain or in 129MM Tg45 mice following challenge with prions from 129MM vCJD patient appendix [24].