PRNP and variant Creutzfeldt-Jakob disease: Notably, type 4 PrPSc propagation does not result in typical vCJD neuropathology in these mice and instead is associated with large non-florid PrP plaques in the corpus callosum accompanied by diffuse synaptic PrP deposition and occasional small non-florid PrP plaques in the brainstem and thalamus [9].