PRNP and variant Creutzfeldt-Jakob disease: 7/14 of the infected mice propagated type 5 PrPSc (Figs 1A and 2A) accompanied by the presence of characteristic irregular, non-florid PrP plaques in the corpus callosum (Fig 1B) that precisely mirrored what would be expected after transmission of prions from 129MM vCJD patient brain to these mice.