PRNP and variant Creutzfeldt-Jakob disease: The transmission properties of 129VV Tg152c mouse brain with type 5 PrPSc and PrP plaques in the corpus callosum was entirely consistent with the previously documented transmission properties of type 5 PrPSc isolates from 129VV Tg152 mice produced after challenge with 129MM vCJD patient brain [8,9].