PRNP and variant Creutzfeldt-Jakob disease: Infected vCJD-challenged human PrP 129V mice propagate a novel prion strain associated with type 5 PrPSc [6,8,10,25] which shares the same predominance of the diglycosylated PrP glycoform seen in type 4 PrPSc but is distinguished by proteinase K digestion products of greater molecular mass, indicative of a distinct PrPSc conformation [6,8,10,25].