Recent scRNA-seq studies, despite being based on a small sample size and using a different study design, have identified specific molecular fingerprints of fibrotic strictures and uncovered the heterogeneity of fibroblasts within intestinal strictures.10 Interestingly, GREM1+ fibroblasts have emerged in other studies as key regulators of intestinal fibrosis, which supports our findings and strengthens the case for GREM1 as a promising therapeutic target.11,42. This evidence concerns the gene GREM1 and fibrosis.