However, the expression of SOX2 shows significant variability within this type of cancer, with markedly higher levels of SOX2 mRNA and protein identified in androgen-independent cell lines such as DU 145, PC-3, PC-3 M, PC-3 M-1 E8, PC-3 M-2B4, NCI-H660, 42D-ENZR, C4-2 ENZR, LNCaP abl, LASCPC and MSK-EF1 [35–37]. This evidence concerns the gene SOX2 and cancer.