On the other hand, OBS increased liver and kidney Nrf2 (by approximately 1.7- to 1.6-fold), HO-1 (by approximately 1.6- to 1.4-fold), and Bcl-2 (by approximately 1.6- to 1.4-fold) mRNA expression levels and suppressed NF-κB (by approximately 0.7–0.7 fold), TNF-α (by approximately 0.6–0.6 fold), Bax (by approximately 0.8- to 0.7-fold), and Cas-3 (by approximately 0.7–0.7 fold) mRNA expression levels compared to CIS group (p < 0.0001). The gene discussed is TNF; the disease is in situ carcinoma.