MUC1 and chronic kidney disease: Kaplan–Meier analysis of the age at ESKD onset, including familial CKD cases, revealed a median ESKD onset age of 56 years (95% CI 49–70) for ADTKD–UMOD and 47 years (95% CI 42–50) for ADTKD–MUC1, with ADTKD–MUC1 showing a significantly younger onset age (Fig. 2).