HMCN1 and epidermolysis bullosa simplex: Given the fact that the three HMCN1 variants associated with a more severe EBS phenotype were found to affect the hemicentin-1 structure, we hypothesized that (1) hemicentin-1 may contribute to the stability of the BMZ in human skin as previously shown in other species and tissues (Gianakas et al., 2023; Vogel and Hedgecock, 2001; Welcker et al., 2021; Zhang et al., 2022); and (2) that hemicentin-1 deficiency may compromise BMZ integrity and thus may aggravate the consequences of EBS-causing KRT14 variants.