HMCN1 and age-related macular degeneration: To date, hemicentin-1 has been implicated in the pathogenesis of age-related macular degeneration, post-infarction myocardial fibrosis, cancer, and kidney glomerular disease (Chowdhury et al., 2014; Liu et al., 2019; Thompson et al., 2007; Toffoli et al., 2018).