Most cases of EBS are due to pathogenic variants in KRT5 (Lane et al., 1992) and KRT14 (Bonifas et al., 1991; Coulombe et al., 1991, 2009), which encode basal cell keratin intermediate filaments, although additional genes have been associated with EBS pathogenesis as well (Bardhan et al., 2020). The gene discussed is KRT14; the disease is epidermolysis bullosa simplex.