Of note, the wide range of basement membrane proteins that interact with hemicentin-1 (Xu et al., 2013) suggests that HMCN1 variants may possibly modify the phenotypic expression of pathogenic variants associated with additional hereditary disorders of basement membranes (Jayadev and Sherwood, 2017) also associated with clinical variability (Bodemer et al., 2003) and in keratin variant-based diseases other than EBS (Pavlovsky et al., 2022). This evidence concerns the gene HMCN1 and epidermolysis bullosa simplex.