Given the fact that (1) deleterious variants in HMCN1 are associated with severe EBS (Fig. 1 A) and (2) hemicentin-1 directly interacts with K14 (Fig. 4), we hypothesized that hemicentin-1 may contribute to the stability and integrity of the epidermal-dermal junction. Here, HMCN1 is linked to epidermolysis bullosa simplex.