Those four families included 20 individuals affected with EBS due to pathogenic variants in KRT14 (heterozygous c.373C>T, p.Arg125Cys in family 1; heterozygous c.1231_1233delGAG, p.Glu411del in family 2; and homozygous c.1163G>A, p.Arg388His in family 3 and 4) (Fig. 1 A). Here, KRT14 is linked to epidermolysis bullosa simplex.