Furthermore, ZIKV infection reduced the levels of CASP1-p20 in both iBMDMs and BMDMs treated with LPS plus Ni (Fig. 2C and D), as well as the levels of CASP3-p17 and CASP7-p20 in both cell types treated with TNF plus CHX (Fig. 2C and D). Here, TNF is linked to Zika virus infectious disease.