GDF15 and Cachexia: The presented abnormalities in the POLG mice are reminiscent of the symptoms of PMM in patients, which prompted us to examine the effects of GDF15 neutralization in these mice with a selective and potent monoclonal anti‐GDF15 antibody (mAB2), which has demonstrated robust efficacy in reversing tumour‐ or cisplatin‐induced cachexia in our previous studies [14, 16].