IGF1 and metabolic dysfunction-associated steatotic liver disease: Similarly, there were no changes detected in IGF-1 protein levels, whose deficiency has been linked to liver pathology and non-alcoholic fatty liver disease (NAFLD; Hribal et al., 2013; Ichikawa et al., 2007), and its decrease is evident in Smn2B/- mice (Deguise et al., 2021b).