SMN1 and proximal spinal muscular atrophy: Hence, aside from elucidating the impact of liver-specific SMN depletion on hepatic function, it is imperative to explore its effects on other tissues, as alterations in these tissues have been documented in various mouse models of SMA (Bowerman et al., 2012b; Deguise et al., 2021b; Hua et al., 2011; Hua et al., 2015).