To confirm the role of SIRT3 in regulating DRP1K711 acetylation, we generated a SIRT3 conditional knockout (CKO) mouse by injecting pAAV‐TH‐Cre‐WPRE‐hGHpA virus into the SNc of SIRT3flox/flox mice (verified via genotyping; Figure S12, Supporting Information) SIRT3 CKO and control mice were further treated with MPTP to generate PD mouse models (Figure8A). The gene discussed is TH; the disease is Parkinson disease.