SIRT3 and Parkinson disease: Abnormal fission caused by DRP1 induces excessive ROS production and triggers the caspase‐3‐dependent death pathway by releasing cytochrome c into the cytoplasm.[66] In various disease models, inhibition of DRP1 activation reverses these changes and restores the mitochondrial function and morphology.[67, 68, 69] This study confirmed the crucial role of SIRT3 in protecting DA neurons by regulating DRP1K711 acetylation in a PD model.