To investigate the neuroprotective effects of SIRT3 in vivo, we used MPTP which is a lipid – soluble compound that can cross the blood–brain barrier and is metabolized in the brain to the toxic MPP+ to establish a subacute PD mouse model (Figure7A) and 6‐hydroxydopamine (6‐OHDA) to establish an acute PD mouse model (Figure S11A, Supporting Information). This evidence concerns the gene SIRT3 and Parkinson disease.