PIEZO1 and posterior cortical atrophy: Considering that Piezo1 is elevated in PCa, this could indicate that the mechanical effects of FUS alone can both activate and potentially downregulate expression of Piezo1 over time, which would require further studies to fully explore since there is a general lack in knowledge regarding how Piezo1 expression is affected by mechanical forces.[105] Piezo1 expression remained quite high for most treatment regimens, and dramatically decreased for the 0.5 and 1 h treatment intervals (Figure 7H).