Unlike Piezo1, expression of some of the TRP channels, such as TRPC1 and TRPM8, decrease with the progression of PCa and are not as prognostic in the diagnosis of disease.[51, 90, 91] We continued these mechanistic studies and knocked down PIEZO1 in PC3 cells to further confirm our results (Figure 4I–L), showing less apoptosis for FUS+TRAIL treatment compared to the control groups. The gene discussed is TRPM8; the disease is posterior cortical atrophy.