Therefore, the transport of TRAIL throughout the tumor is expected to be slow and it is unlikely that the drug will be fully cleared from the tumor during the treatment timeline of this study.[30, 35] Antibody drug conjugates injected intratumorally have been shown to have a half‐life of 27 days, and these molecules are generally larger in size than TRAIL.[100, 101] Specifically, the 0 and 4 h treatment intervals were shown to be most effective for reducing PCa tumor burden (Figure 7B) and slowing tumor growth (Figure 7C). This evidence concerns the gene TNFSF10 and posterior cortical atrophy.