Considering that the mean DR4 expression is lowest for the TRAIL (47.0%) and combination‐treated tumors (49.6%), this could be due to DR4 receptor internalization once TRAIL has become bound to its receptor on the cancer cells (Figure 6F).[64] These results are consistent with the 24 h timepoint in Figure 5A as determined by the apoptosis profiler. This evidence concerns the gene TNFRSF10A and cancer.