Altogether, these observations illustrate that Piezo1 is an integral component to mediate the enhanced TRAIL sensitization observed when FUS is applied to mechanically evoke intrinsic tumor cell apoptosis, as pre‐treatment of PC3 cells with 2‐APB showed that TRP activation via FUS is not the primary mechanism driving enhanced apoptosis following FUS+TRAIL therapy. The gene discussed is TNFSF10; the disease is neoplasm.