PIEZO1 and cancer: Our previous research showed that combination treatment of cancer cells with TRAIL and physiologically relevant fluid shear stress (FSS) enhanced TRAIL‐mediated cell death and TRAIL sensitization.[12, 23, 24, 25, 26] Further examination of this mechanism determined that the mechanosensitive ion channel (MSC), Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1), was mechanically opened and activated in response to the membrane tension induced by the shear forces.