ACE and hypertensive disorder: In the AHA 2024 GL, hypertension screening among adults has I/C, <130/80 mmHg target BP level to prevent stroke has I/A, the recommended drug classes (thiazide and thiazide-like diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers) for stroke prevention has I/A and the use of combination therapy has also I/A recommendation based on “abundant high-quality RCTs and systematic reviews/meta-analyses” [29–35].