SIRT2 and hepatocellular carcinoma: Thus, combining elesclomol with the SIRT2‐specific inhibitor AGK2 induces cuproptosis in gastric tumors both in vitro and in vivo.[24] MELK enhances the expression of the cuproptosis‐related signature gene DLAT, particularly by increasing the DLAT monomer portion through the activation of the PI3K/mTOR pathway, thereby facilitating the progression of HCC.[50] In our study, we found that the copper ion content was significantly elevated in TNBC tissues and was closely associated with prognosis.