NEDD4 and breast cancer: Copper levels are elevated in tumors and play a potential role in tumorigenesis, including breast cancer.[26, 27] As a major copper transporter, copper transporter 1 (CTR1) is tightly regulated at the transcriptional level by HIF1α and C‐myc and at the post‐translational modification level by Nedd4‐1 and AMPK, leading to copper elevation in tumors.[28, 29] Consistent with these findings, copper levels were significantly elevated in TNBC tissues compared to adjacent tissues (Figure1A) and were positively correlated with advanced stages and poor prognosis in patients (Figure 1B,C).