HECTD2 and cancer: HECT domain E3 ubiquitin protein ligase 2 (HECTD2), a member of the HECT‐type E3 ligase family members, was first identified as a susceptibility gene for neurodegenerative disorders.[5, 6] As a relatively understudied member of the HECT E3 ligase family, HECTD2 has recently been implicated in diverse roles in human cancers.