One of the key mechanisms of AMPK activation is the phosphorylation of Thr172 on the α‐subunit.[32] Recent studies have suggested that the loss of HDAC11 activates AMPK signaling pathway by promoting histone acetylation in the liver kinase B1 (LKB1) promoter region in HCC cell lines, thereby suppressing tumor stemness and the progression of HCC. This evidence concerns the gene PRKAA2 and neoplasm.