LKB1, Ca2+/calmodulin‐dependent protein kinase β (CaMKKβ) and transforming growth factor‐β (TGF‐β)‐activated kinase 1 (TAK1) have been identified as direct upstream kinases responsible for phosphorylate AMPK.[35] In addition, HDAC11 has been reported to decrease histone acetylation at the promoter region of LKB1, thereby impeding its transcription and expression in HCC.[33a] Therefore, we investigated the mRNA levels of LKB1, CaMKKβ, and TAK1 in FFA‐induced HepG2 cells treated with B6 (Figure 11H–J). The gene discussed is PRKAA1; the disease is hepatocellular carcinoma.