As demonstrated by the KEGG enrichment analysis (Figure 10A; Figure S5A, Supporting Information), although the AMPK signaling pathway is significantly enriched following intervention on HDAC11, several other relevant pathways, such as the Adipocytokine signaling pathway and the Insulin signaling pathway, also merit further investigation, as they play crucial roles in MASLD. Here, PRKAA2 is linked to metabolic dysfunction-associated steatotic liver disease.