CGAS and neoplasm: Innate immunity is a fundamental defense mechanism that organisms utilize in response to external pathogenic invasion or internal stress.[26] Within the TME, the innate immune response is integral to various antitumor immune processes, including tumor surveillance, antigen presentation, the initiation and sustainment of T cell activity, and the establishment of immune memory.[27] Central to these processes is the cGAS‐STING pathway, which plays a critical role in detecting intracellular dsDNA signals and initiating type I IFNs‐dependent innate immune responses.