CASP3 and epilepsy: Recent studies have shown that lncRNA-PVT1 is highly expressed in the hippocampal tissue of rats with epilepsy, and silencing PVT1 improves spatial learning and memory ability, reduces neuronal loss, and decreases the expression of cleaved-caspase 3 and Bax while increasing the expression of pro-caspase-3 and Bcl-2, indicating its pivotal role in neuronal apoptosis.