Epigenetic modifications of RNA, including N6‐Methyladenosine (m6A), 5‐Methylcytosine (m5C), N1‐Methyladenosine (m1A), ac4C, and others, are prevalent across eukaryotic systems and exert critical influences on RNA structure and function.[58] Among these, ac4C has recently emerged as a key regulator of RNA stability and translation.[59] NAT10, the only known RNA acetyltransferase that catalyzes ac4C modification, has been implicated in tumorigenesis by increasing ac4C levels, highlighting its crucial role in cancer progression. Here, NAT10 is linked to cancer.