CDK1 and neoplasm: Maintaining proliferation signals, evading growth inhibitors, resisting cell death, and achieving replicative immortality are key hallmarks of cancer.[52] The cell cycle, a series of tightly regulated events, drives cellular growth and proliferation.[53] Studies have demonstrated that CDK1 is a crucial regulator of the cell cycle in most mammalian cells.[54] Dysregulation of CDK1 can lead to abnormal tumor proliferation and chromosomal instability.[33] Recently, Menon et al.