In the cytoplasm, YBX1 tends to promote tumor progression by stabilizing mRNA.[30, 31, 32] To elucidate the biological pathways through which the CD2BP2‐DT/YBX1 axis drives breast cancer proliferation and identify its downstream targets, we conducted RNA sequencing after CD2BP2‐DT knockdown, which revealed 4236 DEGs (|log FC| > 0.585, p < 0.05) (Figure4A; Figure S4A, Supporting Information). This evidence concerns the gene CD2BP2 and breast cancer.