Specifically, the physiological topology of the brain TSPO density was investigated in healthy conditions; then, the ability of the model to unveil alterations in regional neuroinflammatory load was tested for different published studies on patients with psychiatric disorders (risk of psychosis and schizophrenia 41), neurodegenerative disease (Alzheimer’s disease 42), and a chronic pain condition (fibromyalgia 43), as well as on a target blocking 44 and a test-retest study 42. The gene discussed is TSPO; the disease is Alzheimer disease.