Additionally, the research assessed regional tau accumulation in brain areas known for their vulnerability in early Alzheimer’s disease stages, specifically the MTL and DMN (Huijbers et al., 2019; Gardini et al., 2021), and incorporated groups of brain regions targeted by tau pathology and how it spreads in accordance with Braak staging. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.