Despite technological advancements in brain imaging and the increasing popularity of functional connectivity in the field of Alzheimer’s disease research, significant knowledge gaps remain regarding the precise mechanisms linking Alzheimer’s disease biomarker accumulation and local functional connectivity patterns within brain networks and regions vulnerable to Alzheimer’s disease pathology (Aβ and tau), such as the MTL and DMN. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.