KDM5B and Cognitive impairment: The pleiotropic associations of common variants with both cognitive function and bone density parallel results from recent studies of rare variants: A study of rare protein coding variation in relation to verbal-numerical reasoning in the UKB also identified a genetic locus (KDM5B) with pleiotropic effects on bone mineral density, and KDM5B mutant mice showed both cognitive deficits and skeletal abnormalities45.