In contrast, other genes were downregulated in these fibroblasts including NLRP2, FUCA1, CLCA4, and RNF186 in Crohn’s and RALGPS1, DLG3, STON2, and FMO5 in UC derived IBD Chips (Extended Data Fig. 3C,D), which is again consistent with results of transcriptomic analyses carried out on IBD patient tissues31–33. This evidence concerns the gene RNF186 and inflammatory bowel disease.