ECM2 and inflammatory bowel disease: When stromal cells cultured in IBD Chips were similarly analyzed, they displayed expression of IBD-relevant genes with Crohn’s fibroblasts overexpressing ITGA7, FXD1, HGF, FZD7, NKX2–3, LOXL3 relative to healthy fibroblasts, while high levels of IKBIP, NKX2–3, ADA2, ECM2, NDN, SLC22A17 were seen in UC fibroblasts (Extended Data.