CLDN6 and cancer: Differential gene expression analysis showed overexpression of classic epithelial genes (e.g., SFTPC and STEAP1), genes associated with cancer (e.g., CLDN6), and regulators of EMT (e.g., vimentin, fibronectin 1, and N-cadherin) in Oncopig LC versus normal pig lung tissues (Fig. 5B).