Interestingly, three cases with traditional AML-defining gene fusions that have routinely been evaluated by cytogenetic analysis for decades, were only identified by iWGS-WTS, including CBFB::MYH11 (SJ032253), RBM15::MRTFA (SJ030209), and KMT2A::MLLT10 (SJ030361). The gene discussed is CBFB; the disease is acute myeloid leukemia.