Indeed, iWGS-WTS identified AML-defining genetic alterations in 7 of these 9 cases (1 KMT2A::ELL, 1 RBM15::MRTFA, 1 NUP98::KDM5A, 1 NPM1 mutation, and biallelic alterations of TP53 in 3 cases), and revealed a CDK6::HOXA10 and a TEC::MLLT10 (rarely reported in-frame fusion) in the remaining two cases, SJ030410 and SJ030773, respectively (Supplementary Table S6B). Here, NPM1 is linked to acute myeloid leukemia.