Given that genomic profiling revealed characteristics similar to T-ALL with t(5;14)(q35;q32) in both cases (13, 14, 15), including alterations in PHF6 and focal deletions of CDKN2A/B, we also evaluated the expression of TLX3 and NKX2–5. This evidence concerns the gene CDKN2A and acute lymphoblastic leukemia.