Heterozygous P/LP germline alterations in genes known to predispose to hematologic neoplasms with autosomal dominant inheritance were identified in six patients, including variants in CHEK2 (seen in 2 patients), ETV6, RUNX1 and TP53, as well as intragenic deletions in PALB2 and UBE2T. This evidence concerns the gene RUNX1 and hematopoietic and lymphoid system neoplasm.