Given that genomic profiling revealed characteristics similar to T-ALL with t(5;14)(q35;q32) in both cases (13, 14, 15), including alterations in PHF6 and focal deletions of CDKN2A/B, we also evaluated the expression of TLX3 and NKX2–5. The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.