The most significant SNP was rs148303016 (PASSET = 6.26 × 10−15, PCPASSOC = 3.96 × 10−18) located within poliovirus receptor-related 2 (PVRL2), followed by rs7575209 (PASSET = 3.69 × 10−17, PCPASSOC = 1.66 × 10−14) located within bridging integrator-1 (BIN1), which is a major AD susceptibility gene (Lambert et al., 2022). Here, BIN1 is linked to Alzheimer disease.