The loci 7p21.3, 11q14.2, and 14q32.12 were mapped to transmembrane protein 106B (TMEM106B) (Satoh et al., 2014), phosphatidylinositol binding clathrin assembly protein (PICALM) (Ando et al., 2022), and sodium/potassium/calcium exchanger 4 (SLC24A4) (Yu et al., 2015) genes associated with AD, respectively. The gene discussed is PICALM; the disease is Alzheimer disease.