LEPR and neoplasm: conducted experiments to verify that CAFs generated by the proliferation of intestinal crypt peripheral leptin receptor (Lepr) cells shape the tumor-promoting immune microenvironment by expressing melanoma cell adhesion molecule (MCAM) and interacting with interleukin 1 receptor 1, which induces nuclear factor κB-IL34/CCL8 signaling to enhance M2-type macrophage chemotaxis (29).