In 2013, The Cancer Genome Atlas (TCGA) project classified EC into four molecular subtypes through whole-genome analysis: (i) ultra-mutated endometrial cancer with mutations in the exonuclease domain of DNA polymerase epsilon (POLE), (ii) hypermutated endometrial cancer with microsatellite instability, (iii) copy-number-high endometrial cancer with frequent TP53 mutations, and (iv) the copy-number-low group of endometrial cancers (7). This evidence concerns the gene POLE and endometrial cancer.